Reagent Kit HemeScreen® HRM Screening NPM1 For use with HRM-enabled RT-PCR Machine / AML Panel 100 Tests
Precipio’s HemeScreen® offerings are Research Use Only (RUO) assays that screen for clinically actionable somatic mutations in targets of interest related to myeloproliferative disorders and haematological cancers
Product Specifications
Description
The reagents are designed to be used in a clinical diagnostic laboratory by suitably trained personnel testing DNA extracted from whole blood or bone marrow using a PCR-based method and High Resolution Melt (HRM) Analysis
NPM1 (Nucleophosmin 1) mutations are most common (~50% of cases), and are usually seen in conjunction with other AML-associated mutations
NPM1 mutations have been suggested as a monitoring tool for MRD due to its stable nature during the course of disease; NPM1 mutation has a favorable prognosis when it is the only abnormality
Machine required HRM-enabled RT-PCR (example/ ThermoFisher Quantstudio 3 or higher)
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