Reagent Kit HemeScreen® HRM Screening MPN Panel For use with HRM-enabled RT-PCR Machine
HemeScreen® BCR/ABL1 screening reagents are research use only reagents that screen for three major BCR/ABL1 isoforms (p190, p210, and p230) and one minor isoform (p203) associated with BCR/ABL1-induced leukemogenesis, including chronic myeloid leukemia (CML) and acute lymphocytic leukemia (ALL)
Product Specifications
Description
The HemeScreen® MPN Panel offerings are research use only assays that screen for somatic mutations in targets of interest related to myeloproliferative disorders
This reagent set is specifically designed to screen for mutations using High Resolution Melt Analysis in JAK2, MPL and CALR genes
This reagent set is designed for use by suitably trained personnel testing DNA extracted from whole blood or bone marrow samples using a RT-PCR-based method, or High Resolution Melt (HRM) Analysis
The HemeScreen® HRM Screening Reagents indicate the presence of a potential mutation within a sample but does not confirm the identity of the mutation; to confirm the precise mutation detected, further analysis, such as TaqMan™ detection assays or DNA sequencing, is required
The HemeScreen® MPN HRM Screening Reagents have been designed to PCR amplify the relevant regions in MPL, CALR, JAK2 exon 12, JAK2 exon 13 and JAK2 exon 14 genes for subsequent HRM analysis
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